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Preimplantation Genetic Diagnosis (PGD)
Parents wish for their children to be healthy. They cannot change their own genetics but parents do have the option, and most feel they have the obligation, to provide their future children a chance for the best life possible and to spare them inherited debilitating genetic disease. IHR has the experience and the expertise to assist these couples to make the best reproductive choice suitable for them to conceive a healthy baby, and the understanding of the emotional roller-coaster, which they are going through.

Preimplantation Genetic Diagnosis, also known as PGD, is the diagnosis of a genetic condition prior to achievement of a pregnancy, as a way for couples to conceive a healthy child. This form of genetic testing is performed on eggs or embryos during an in vitro fertilization (IVF) treatment. This allows parents to avoid the very difficult dilemma of aborting an affected pregnancy or raising a sick child. PGD was first performed in 1990 both in Chicago (testing the egg) and in London (testing the embryo). In order to be able to perform PGD, the patients have to undergo in vitro fertilization (IVF) treatment. IHR provides one of the most experienced and successful IVF services with preimplantation genetic diagnosis in the world. In addition to hundreds of IVF/ICSI treatment cycles performed annually for infertility, Dr. Tur-Kaspa, IHR’s Medical Director, conducted personally more than 1000 IVF-PGD cycles in the last few years for patients with over 50 different single gene genetic disorders (such as Cystic Fibrosis, Fragile-X syndrome, Muscular Dystrophy, Thalassemia, Sickle cell anemia, Huntington disease, and Hereditary cancer predisposition genes), chromosomal translocations, for HLA matched child, and for aneuploidy. Currently, we are able to perform PGD for almost any known genetic conditions including single gene disorders and/or for chromosomal abnormalities. IHR collaborate with the Reproductive Genetic Institute, a word known Chicago based PGD laboratory. The IHR IVF-PGD experts work closely with couples undergoing the many different types of assisted fertility treatments and PGD methods available. We are renowned for our specialized knowledge and high infertility success rates even in difficult cases. IHR's expertise in preimplantation genetic diagnosis lies in our willingness and ability to individualize our approach to best suit each and every one of our patients. If you have any questions as you review the material on preimplantation genetic diagnosis, please contact us for a FREE Preimplantation Genetic Diagnosis E-Mail Consultation.

Preimplantation genetic testing is a technique used to identify genetic defects in embryos created through in vitro fertilization (IVF) before pregnancy. Preimplantation genetic diagnosis (PGD) refers specifically to when one or both genetic parents have a known genetic abnormality and testing is performed on an embryo to determine if it also carries a genetic abnormality. In contrast, preimplantation genetic screening (PGS) refers to techniques where embryos from presumed chromosomally normal genetic parents are screened for aneuploidy. Because only unaffected embryos are transferred to the uterus for implantation, preimplantation genetic testing provides an alternative to current post-conception diagnostic procedures (ie, amniocentesis or chorionic villus sampling), which are frequently followed by the difficult decision of pregnancy termination if results are unfavorable. PGD and PGS are presently the only options available for avoiding a high risk of having a child affected with a genetic disease prior to implantation. It is an attractive means of preventing heritable genetic disease, thereby eliminating the dilemma of pregnancy termination following unfavorable prenatal diagnosis.

Through PGD techniques, we are able to test for many different genetic diseases. Some of our families request PGD for a specific genetic condition running in their family, such as cystic fibrosis, Tay Sachs disease, muscular dystrophy or Fragile X syndrome. Other couples request genetic testing for chromosome problems, such as Down syndrome, trisomy 18, trisomy 13 and Marfan syndrome, and in order to improve their chances of getting pregnant during in vitro fertilization. By choosing to pursue PGD, you will significantly reduce the chances for your baby to be affected with a specific genetic condition.

In addition, in the course of the PGD/PGS procedure, doctors receive information on the predicting gender, which is useful to prevent X-linked disorders and for family balancing.

IHR offer advanced treatments for a variety of conditions, including female and male infertility, unexplained infertility, diminished ovarian reserve, ovulatory dysfunctions, endometriosis, immunological infertility, egg donation, surrogacy, and many others. Perhaps less known is our work with individuals and couples who are considering assisted reproduction, but who are uncertain of their next step. We encourage anyone, before they make a decision, to consult with us. Currently, we are offering a FREE Preimplantation Genetic Diagnosis E-Mail Consultation.